O-LINKED SUGARS “Varietas delectat”
Mucin-type glycans appear in higher eukaryotes singly or in clusters and provide a platform for the addition of histo-blood group antigens or polylactosaminoglycans.
Classification recognizes 8 mucin type cores
G. Hart: O-GlcNAc glycosylation competing with phosphorylation of HO-groups of amino residues may regulate the transcription
( RNA polymerase II, cMyc, HT29 colon cancer cells).
Initiates formation of many proteoglycans